Octopus sleep is surprisingly similar to humans and contains a wake-like
stage

Date:
June 28, 2023
Source:
Okinawa Institute of Science and Technology (OIST) Graduate
University
Summary:
Researchers have closely examined the brain activity and skin
patterning in octopuses (Octopus laqueus) during active sleep
and discovered that it closely resembles neural activity and skin
patterning behavior seen when awake.


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When octopuses sleep, their quiet periods of slumber are punctuated by
short bursts of frenzied activity. Their arms and eyes twitch, their
breathing rate quickens, and their skin flashes with vibrant colors.

Now, researchers from the Okinawa Institute of Science and Technology
(OIST), in collaboration with the University of Washington, have closely examined the brain activity and skin patterning in octopuses (Octopus
laqueus) during this active period of sleep and discovered that they
closely resemble neural activity and skin patterning behavior seen when
awake. Wake-like activity also occurs during rapid eye movement (REM)
sleep in mammals -- the phase in which most dreams occur.

The study, published 28 June inNature, highlights the remarkable
similarities between the sleeping behavior of octopuses and humans and
provides fascinating insights about the origin and function of sleep.

"All animals seem to show some form of sleep, even simple animals like jellyfish and fruit flies. But for a long time, only vertebrates were
known to cycle between two different sleep stages," said senior author, Professor Sam Reiter, who leads the Computational Neuroethology Unit
at OIST.

"The fact that two-stage sleep has independently evolved in distantly
related creatures, like octopuses, which have large but completely
different brain structures from vertebrates, suggests that possessing an active, wake-like stage may be a general feature of complex cognition,"
said author Dr. Leenoy Meshulam, a statistical physicist at the University
of Washington, who helped design the research during her three month
stay at OIST as a guest of the Theoretical Sciences Visiting Program.

To begin, the scientists checked whether the octopuses were truly asleep
during this active period. They tested how the octopuses responded to a physical stimulus and found that when in both the quiet and active stage
of sleep, the octopuses required stronger stimulation before reacting,
compared to when they were awake. The team also discovered that if they prevented the octopuses from sleeping, or disrupted them during the
active phase of sleep, the octopuses later entered active sleep sooner
and more frequently.

"This compensatory behavior nails down the active stage as being an
essential stage of sleep that is needed for octopuses to properly
function," said Aditi Pophale, co-first author of the study and PhD
student at OIST.

The researchers also delved into the brain activity of the octopuses when
awake and asleep. During quiet sleep, the scientists saw characteristic
brain waves that closely resemble certain waveforms seen during non-REM
sleep in mammalian brains called sleep spindles. Although the exact
function of these waveforms is unclear even within humans, scientists
believe they aid in consolidating memories. Using a cutting-edge
microscope built by co-first author Dr. Tomoyuki Mano, the researchers determined that these sleep spindle-like waves occur in regions of the octopuses' brains associated with learning and memory, suggesting that
these waves potentially serve a similar function to humans.

Roughly once an hour, the octopuses entered an active sleep phase for
around a minute. During this stage, the octopuses' brain activity very
closely resembled their brain activity while awake, just like REM sleep
does in humans.

The research group also captured and analyzed the changing skin patterns
of the octopuses when awake and asleep in ultra-high 8K resolution.

"By filming in such high resolution, we can see how each individual
pigmented cell behaves in order to create an overall skin pattern,"
said Dr. Meshulam.

"This could help us create simple skin pattern models to understand
the general principles of waking and sleeping patterning behavior."
When awake, octopuses control thousands of tiny, pigmented cells in
their skin, creating a vast array of different skin patterns. They use
these patterns to camouflage themselves in different environments,
and in social or threat displays, such as warning off predators and communicating with each other.

During active sleep, the scientists reported that the octopuses cycled
through these same skin patterns.

The similarities between active sleep and awake states could be explained
by a variety of reasons, said the scientists. One theory is that octopuses
may be practicing their skin patterns to improve their waking camouflage behavior, or simply maintaining the pigment cells.

Another intriguing idea is that the octopuses could be re-living and
learning from their waking experiences, such as hunting or hiding
from a predator, and reactivating the skin pattern associated with
each experience. In other words, they could be doing something similar
to dreaming.

"In this sense, while humans can verbally report what kind of dreams
they had only once they wake, the octopuses' skin pattern acts as a
visual readout of their brain activity during sleep," said Prof. Reiter.

He added, "We currently don't know which of these explanations, if any,
could be correct. We are very interested in investigating further."
* RELATED_TOPICS
o Plants_&_Animals
# Animal_Learning_and_Intelligence # Behavioral_Science
# Biology # Molecular_Biology # Cell_Biology # Mice #
New_Species # Evolutionary_Biology
* RELATED_TERMS
o Sleep o Octopus o Dog_skin_disorders o Itch o Skin o
Ultraviolet o Sleep_disorder o Leopard

========================================================================== Story Source: Materials provided by Okinawa_Institute_of_Science_and_Technology_(OIST)
Graduate_University. Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Aditi Pophale, Kazumichi Shimizu, Tomoyuki Mano, Teresa L. Iglesias,
Kerry Martin, Makoto Hiroi, Keishu Asada, Paulette Garci'a Andaluz,
Thi Thu Van Dinh, Leenoy Meshulam, Sam Reiter. Wake-like skin
patterning and neural activity during octopus sleep. Nature, 2023;
DOI: 10.1038/s41586- 023-06203-4 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/06/230628130356.htm

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