Study uncovers gut bacteria differences in children who later develop
juvenile idiopathic arthritis

Date:
July 6, 2023
Source:
University of Florida
Summary:
For the first time, scientists have shown that gut bacteria
differences are associated with later development of juvenile
idiopathic arthritis, a debilitating rheumatic childhood disease,
and that these differences are present years before the disease
is diagnosed.


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For the first time, scientists have shown that gut bacteria differences
are associated with later development of juvenile idiopathic arthritis,
a debilitating rheumatic childhood disease, and that these differences
are present years before the disease is diagnosed.

The research team, which includes scientists from the University of
Florida and researchers in Sweden, made this discovery by analyzing
stool samples from one- year-old children in a long-term study called
All Babies in Southeast Sweden.

The scientists compared bacteria found in children who went on to develop juvenile idiopathic arthritis with those who did not.

"Our work suggests that an imbalance in microbes, especially the increased prevalence of several proinflammatory bacterial species, could serve
as a potential indicator of future disease risk," said Angelica Ahrens, co-first author of the study and a postdoctoral associate in the UF/IFAS department of microbiology and cell science.

Juvenile idiopathic arthritis, or JIA, which is also called childhood
arthritis and pediatric rheumatic disease, is an autoimmune disease
marked by inflammation of the joints and sometimes other parts of the
body. Children with JIA experience pain, swelling, stiffness and other
symptoms that make daily activities challenging. Current treatments for
JIA include anti-inflammatory drugs and steroid injections.

"These treatments can help control inflammation and reduce symptoms,
but they are not without their drawbacks and they do not cure the
disease. There is a need to find alternative approaches, and the bacteria
found in gastrointestinal tract may be a promising place to start,"
said Dr. Erik Kindgren, co-first author of the study and a pediatrician
at Skaraborg Hospital in Sweden who treats children with JIA.

While other studies have shown microbial differences in children already diagnosed with JIA, this study is the first to demonstrate that these differences are present years before children first show symptoms of
the disease.

The study found that children with gut bacteria known to cause
inflammation were nearly seven times more likely to develop JIA. The researchers also found that bacteria known to promote a healthy gut lining
were absent or reduced in children who later developed the disease. These trends held true even when the researchers controlled for factors already associated with the disease, such as being breastfed for shorter periods
or early exposure to antibiotics.

The scientists say the findings are a first step toward understanding
what causes JIA -- the term "idiopathic" in the name means the cause of
the condition is unknown.

"Looking ahead, this line of discovery could lead to the development
of screening tools in early pediatric wellness visits. By constructing
risk profiles and implementing targeted interventions and preventative
measures to reduce those risks, we may be able to prevent disease onset
in some people," Ahrens said.

First, though, researchers will need to understand how the bacteria
identified in the study contribute to the disease.

"Functionally, what are these bacteria doing in the body that leads to
this disease? That's what we need to investigate next," Ahrens said.

The current study only looked at a snapshot of the gut microbiome at
one year of age, so future work may investigate how the gut microbiome
of children with JIA progresses over time.

The study's authors -- which also include Eric Triplett, chair of the
UF/IFAS department of microbiology and cell science, and Dr. Johnny
Ludvigsson, senior professor at Linko"ping University and both founder and leader of the All Babies in Southeast Sweden study -- plan to continue
their trans-Atlantic collaboration by examining microbial differences associated with other conditions that appear in childhood.

* RELATED_TOPICS
o Health_&_Medicine
# Arthritis # Joint_Pain # Chronic_Illness # Joint_Health
o Plants_&_Animals
# Bacteria # Microbes_and_More # Microbiology #
Veterinary_Medicine
* RELATED_TERMS
o Arthritis o Mumps o Rocky_Mountain_spotted_fever o Adolescence
o Scoliosis o Vaccination o COPD o Rheumatic_fever

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========================================================================== Journal Reference:
1. Erik Kindgren, Angelica P. Ahrens, Eric W. Triplett, Johnny
Ludvigsson.

Infant gut microbiota and environment associate with juvenile
idiopathic arthritis many years prior to disease onset, especially
in genetically vulnerable children. eBioMedicine, 2023; 93: 104654
DOI: 10.1016/ j.ebiom.2023.104654 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/07/230706124526.htm

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